Efficacy of Venetoclax in combination with Rituximab in Waldenström’s
Macroglobulinemia (VIWA-1)
Venetoclax* / Rituximab
Stepwise dose escalation in all patients with a target dose of 800 mg/d QD PO.
Cycle 1 (28-days cycle)
Venetoclax
200 mg/d QD PO
Day 1-7
400 mg/d QD PO
Day 8-14
800 mg/d QD PO
Day 15-28
Cycle 2 – 12
Rituximab
375 mg/m2 i.v.
Day 1
Venetoclax
800 mg/d QD PO
Day 1-28
DRC
Cycle 1-6
Dexamethasone
20 mg p.o.
Day 1
Rituximab
375 mg/m2 i.v.
Day 1
Cyclophosphamide
100 mg/m2 BID p.o.
Day 1-5
Cycle 7-12
Rituximab
375 mg/m2 i.v.
Day 1
